Interaction Checker
Verify drug-drug & drug-allergy interactions
2,847 interactions indexed
Amlodipine 10mg
Simvastatin 40mg
Severe Interaction Detected
HIGH RISK
Amlodipine may increase the serum concentration of Simvastatin. Risk of myopathy and rhabdomyolysis is increased. The dose of Simvastatin should not exceed 20mg/day when combined with Amlodipine.
FDA Label Warning
Lexicomp Reference
Recommended Alternative
Consider Pravastatin or Rosuvastatin as alternatives — no clinically significant interaction with Amlodipine.
Severity Overview
Severe
5
Moderate
12
Minor
28
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